CP-1S — Acylated GLP-1 Receptor Agonist for Advanced Peptide Research
CP-1S is an acylated GCG-like peptide-1 (GLP-1) receptor agonist research compound engineered through systematic lipidation chemistry to achieve an extended pharmacokinetic profile of approximately 165–184 hours. As a 31-amino acid synthetic analog of human GLP-1(7-37) with 94% sequence homology to the endogenous hormone, CP-1S represents the culmination of iterative structure-activity relationship (SAR) studies spanning fatty acid chain lengths from C-12 to C-20, multiple linker chemistries, and strategic amino acid substitutions — all designed to optimize the balance between albumin binding affinity and GLP-1 receptor (GLP-1R) activation potency. This research compound is supplied exclusively as a high-purity lyophilized powder for in vitro and preclinical laboratory investigation. For research use only. Not for human consumption.
CP-1S occupies a unique position in peptide research due to its well-characterized structural biology, with high-resolution cryo-electron microscopy (cryo-EM) structures of the compound bound to the GLP-1R–Gs protein complex now available in the Protein Data Bank (PDB: 7KI0). This structural detail, combined with extensive published literature on the compound’s intracellular signaling profile, receptor dynamics, and activity across diverse preclinical metabolic models, makes CP-1S an exceptionally well-documented tool compound for investigators studying GLP-1 receptor pharmacology, acylated peptide drug design, incretin biology, and metabolic pathway modulation in laboratory settings.
Product Specifications
- Compound Name: CP-1S (Acylated GLP-1 Receptor Agonist)
- Classification: Lipidated incretin-mimetic peptide analog
- Sequence Length: 31 amino acids (modified GLP-1(7-37) backbone)
- Key Structural Modifications: Aib8 (DPP-4 resistance), Arg34 (site-directed acylation control), Lys26-acylated with C-18 fatty diacid via γGlu-2×OEG linker
- CAS Number: 910463-68-2
- Molecular Formula: C187H291N45O59
- Molecular Weight: 4,113.58 Da
- Purity: ≥99% (HPLC verified)
- Physical Form: Lyophilized (freeze-dried) white to off-white powder
- Solubility: Freely soluble in sterile water and physiological buffers (pH 7.4); DMSO compatible
- Available Sizes: 3 mg | 5 mg | 10 mg
- Storage (Lyophilized): −20°C for long-term storage; 2–8°C acceptable for short-term (≤4 weeks)
- Storage (Reconstituted): 2–8°C; use within 30 days. Avoid repeated freeze-thaw cycles.
- Intended Use: For research use only (RUO). Not approved for human or veterinary use.
