Question 1

What should I look for in a research peptide Certificate of Analysis?

Accepted Answer

A meaningful COA should include: identity confirmation via mass spectrometry, purity analysis via HPLC (≥98%, ideally ≥99%), testing by an ISO/IEC 17025 accredited laboratory, batch-specific results (not generic), and independent verifiability through the lab's own website. If the COA is only available "upon request" rather than published openly, that's a red flag.

Question 2

What is ISO/IEC 17025 accreditation and why does it matter?

Accepted Answer

ISO/IEC 17025 is the international standard for testing and calibration laboratory competence. It ensures the laboratory follows rigorous quality management systems, uses validated methods, maintains traceability, and operates with documented impartiality. For peptide testing, this means the results are reliable, reproducible, and conducted by a genuinely independent facility.

Question 3

Are research peptides legal to purchase in the United States?

Accepted Answer

Yes. Compounds labeled "For Research Use Only" (RUO) are legal to purchase in the United States for research purposes. Federal law does not require institutional affiliation, academic credentials, or a prescription. Products must be clearly labeled as not intended for human consumption and sold exclusively for research use.

Question 4

What is HPLC purity and what percentage is considered research-grade?

Accepted Answer

HPLC (High-Performance Liquid Chromatography) purity measures the percentage of the desired compound in a sample versus impurities. Research-grade peptides should show ≥98% purity. Premium suppliers consistently achieve ≥99%. Purity below 95% may indicate poor synthesis, degradation, or contamination.

Question 5

How can I verify a peptide supplier's COA claims?

Accepted Answer

Look for direct verification links to the testing laboratory's website (not just a PDF from the seller). For example, Janoshik Analytical provides unique URLs for each test that can be checked directly at janoshik.com. If a supplier cannot provide independently verifiable results, their transparency claims may not be credible.

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How to Evaluate Research Peptides: An Evidence-Based Guide